WASHINGTON – Secretary of State nominee Hillary Rodham Clinton intervened at least six times in government issues directly affecting companies and others that later contributed to her husband's foundation, an Associated Press review of her official correspondence found.

The overlap of names on former President Bill Clinton's foundation donor list and business interests whose issues she championed raise new questions about potential ethics conflicts between her official actions and her husband's fundraising. The AP obtained three of the senator's government letters under the Freedom of Information Act.

Pharmaceutical company Merck & Co...a member of the Clinton Global Initiative,.... Merck joined CGI in 2006, when dues were $15,000, and also was a member in 2007 and in 2008, when membership dues rose to $20,000. As part of its commitment to CGI, Merck sponsors public health initiatives around the world, Rose said. Merck joined CGI on its own initiative, she said.

Sen. Clinton wrote a November 2005 letter to Health and Human Services Secretary Mike Leavitt urging approval of the human papillomavirus vaccine. Merck applied in December 2005 for approval of its HPV vaccine, Gardasil, and the vaccine was approved for use in females ages 9 to 26. Merck is still seeking approval for use in older women, Rose said.